全身體積描記系統(tǒng)(猴)產(chǎn)品描述：

（whole-bodyplethysmograph，WBP）可以對(duì)清醒自由活動(dòng)的大動(dòng)物進(jìn)行肺功能及氣道反應(yīng)相關(guān)的測(cè)試，避免了創(chuàng)傷性氣管切開(kāi)術(shù)及麻醉的影響，使實(shí)驗(yàn)過(guò)程簡(jiǎn)便快捷，并適合長(zhǎng)期跟蹤研究。

塔望科技開(kāi)發(fā)的大動(dòng)物全身體積描記系統(tǒng)，可用于猴的測(cè)量。測(cè)量時(shí)可直接將猴椅放入描記器內(nèi)，通過(guò)軟件可實(shí)時(shí)測(cè)量猴子的呼吸參數(shù)。

產(chǎn)品特點(diǎn)

1、適用動(dòng)物：猴；

2、不需要做手術(shù)，操作簡(jiǎn)單；

3、可在動(dòng)物在自然狀態(tài)下呼吸的研究以及長(zhǎng)期跟蹤實(shí)驗(yàn)，適合進(jìn)行藥物初篩；

4、具有藥物氣溶膠霧化模塊；

5、具有自動(dòng)標(biāo)定功能；

6、可選配測(cè)量心電、血壓、體溫、心率等指標(biāo)，可與植入式遙測(cè)設(shè)備聯(lián)合使用；

7、具有分析軟件，數(shù)據(jù)可保存至excel或txt格式；

全身體積描記系統(tǒng)(猴)（檢測(cè)參數(shù)）：

1、Ti：吸氣時(shí)間（s）；

2、Te：呼氣時(shí)間（s）；

3、PIF：最大吸氣流速（ml/s）；

4、PEF：最大呼氣流速（ml/s）；

5、Volbal：吸氣時(shí)間/呼氣時(shí)間；

6、F：呼吸頻率（次/min）；

7、Vt：潮氣量（ml）；

8、Mv：分鐘通氣量（ml）；

9、AV：累積體積（ml）；

10、EF50：呼出50%氣量時(shí)對(duì)應(yīng)的呼氣流速（ml/s）；

11、EIP：吸氣峰值壓力（僅在侵入式法測(cè)量時(shí)有效）；

12、EEP：呼氣峰值壓力（僅在侵入式法測(cè)量時(shí)有效）；

13、TR：松弛時(shí)間；

14、PenH：增強(qiáng)呼氣間歇（enhanced pause）；

15、Rpef：相對(duì)時(shí)間；

適用領(lǐng)域：

1、各種呼吸疾病研究，如：哮喘、肺纖維化、肺損傷、ARDS、肺癌等。

2、安全藥理：藥物對(duì)呼吸系統(tǒng)的影響。

3、睡眠呼吸：監(jiān)測(cè)動(dòng)物低通氣、阻塞性呼吸暫停等。

4、環(huán)境毒理：環(huán)境污染物對(duì)動(dòng)物呼吸的影響。

5、吸入式毒理：染毒物質(zhì)對(duì)呼吸系統(tǒng)的毒性影響。

6、高原醫(yī)學(xué)：高原環(huán)境對(duì)呼吸系統(tǒng)的影響。

7、其它需要對(duì)呼吸參數(shù)評(píng)價(jià)的場(chǎng)合。

我公司可以根據(jù)客戶(hù)的特殊應(yīng)用、特殊需求提供功能定制服務(wù)，也可以提供相關(guān)的實(shí)驗(yàn)服務(wù)，詳情請(qǐng)?jiān)儐?wèn)客服。

型號(hào)說(shuō)明：

用戶(hù)名單：

相關(guān)文獻(xiàn)：

[1]Sun Lingna, Fan Mingrui, Huang Dong, Li Bingqin, Xu Ruoting, Gao Feng, Chen Yanzuo. "Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis" [J]. Biomaterials,  2021.

[2]李寧, 李紅鵬, 張本炎, 張柳, 沈繼敏, 李慶云. "高脂膳食對(duì)小鼠呼吸功能和膈肌纖維的影響及其線(xiàn)粒體機(jī)制" [J]. 中華醫(yī)學(xué)雜志,  2021,101(36):2893-2899.

[3]Xiong Jiaying,  Zhuang Tao, Ma Yurong,  Xu Junyi, Ye Jiaqi, Ma Ru, Zhang Shuang, Liu Xin, Liu Bi-Feng, Hao Chao,  Zhang Guisen,  Chen Yin. "Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain" [J]. European Journal of Medicinal Chemistry, 2021, 226:

[4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, " Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance" [J].Frontiers, 2022.819728:

[5]Yumei Zhou, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, "Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma" [J].Frontiers, 2022. 819747:

[6]Zheng R, Yang W, WenYet al. "Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening"  [J].Cell Death Dis 13, 559 (2022).

[7]Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X. "Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy"  [J].PeerJ 10:e13632.

[8]Dongyi Zhu, Qian Zhang, Qinchuan Li, Guangxue Wang, Zhongliang Guo. "Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway" [J].The Journal of Gene Medicine, Volume24/Issue9/September 2022/e3442.

[9]Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J].Aging CellVolume 21, Issue 8 e13680.

[10]Yapeng, LuPanpanChang, WangwangDing, JiangpeiBian, DanWang, XuetingWang, QianqianLuo, XiaomeiWu, LiZhu. "Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells" [J].European Journal of Pharmacology, Volume 929, 15 August 2022, 175137.

[11]Mengjun Zhanga, Huiyang Jiang, Lan Wu,  Haoyu Lu, Hriday Bera, Xing Zhao, Xiong Guo, Xulu Liu, Dongmei Cun, Mingshi Yang. "Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment" [J]. Journal of Controlled Release, Volume 352.

[12]Xue Lu, Zhu-Xia Tan, Wen-Jing Wang, Ping Zhan, Yan Wang, Lin Fu, Lan Gao, Hui. Zhao, Hua Wang, De-Xiang Xu. "Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice" [J]. Environmental Pollution, Volume 315, 120462.

[13]Gu W, Lei J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma [J].Mol Biol Rep 49, 9283–9296 (2022).

[14]Hu M, Yang J, Xu Y, Liu J. MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake. Computational and Mathematical Methods in Medicine  [J]. Hindawi Computational and Mathematical Methods in Medicine/Volume 2022, Article ID 2023500, 15 pages.

[15]Zhou J, Chen H, Wang Q, Chen S, Wang, R, Wang Z, Yang C, Chen A, Zhao J, Zhou Z, Mao Z, Zuo G, Miao D, & Jin J. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J]. Aging Cell, 21, e13680.

[16]WenJing Wang , Xue Lu , Zhao Li , Kun Peng , Ping Zhan , Lin Fu , Yan Wang , Hui Zhao , Hua Wang , De-Xiang Xu , Zhu-Xia Tan."Early-life cadmium exposure elevates susceptibility to allergic asthma in ovalbumin-sensitized and challenged mice"[J] Ecotoxicology and Environmental Safety 255 (2023) 114799

[17]Zhou Y, Hu L, Zhang H, Zhang H, Liu J, Zhao X, Wang J, Wang Q."Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells."[J].Frontiers in Pharmacology, 14 Oct 2022, 13:978421

[18]Bao XC, Wang N, Xu J, Ma J and Fang Y-Q (2023) “Effects of different simulated submarine escape depths by free ascent in animal models. “[J]Front. Physiol. 14:1107782.

[19]Haiyun Chen, Qiuyi Wang, Jie Li, Yuan Li, Ao Chen, Jiawen Zhou, Jingyu Zhao,

Zhiyuan Mao, Zihao Zhou, Yue Wang, Rong Wan, Qing Li, Yongjie Zhang, Runqiu Jiang,Dengshun Miao, Jianliang Jin, “IFN Transcribed by IRF1 in CD4 + Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis" [J]. Aging and Disease, DOI: 10.14336/AD.2023.0320

[20]Yimeng Shu, Ming Ma, Xiaoxia Pan, Muhammad Shafiq, Huizhu Yu, Hangrong Chen,Cobalt protoporphyrin-induced nano-self-assembly for CT imaging, magnetic-guidance, and antioxidative protection of stem cells in pulmonary fibrosis treatment,[J]Bioactive Materials,Volume 21,2023,Pages 129-141,ISSN 2452-199X