產(chǎn)品描述

塔望科技開發(fā)的小動物頭外置體積描記系統(tǒng)（Head-Out Plethysmography），采用特殊設(shè)計(jì)，使小動物的頸部與身體隔開，口鼻暴露在外面，實(shí)時(shí)測定容納身體的腔室內(nèi)氣體容積與壓力的變化。Glaab等對哮喘小鼠使用mACh激發(fā)后，取呼氣中段流量(EF50 )下降55％時(shí)的mACh量( EF50)為指標(biāo)來表示支氣管反應(yīng)的敏感性，研究證明，EF50和RL及CL有較好的相關(guān)性，可較好地反映呼吸系統(tǒng)的機(jī)械動力學(xué)改變。

產(chǎn)品特點(diǎn)

小動物頭外置體積描記系統(tǒng)采用頭外置式體積描記系統(tǒng)測量過程中，動物保持清醒狀態(tài)，不需要麻醉，避免了創(chuàng)傷性氣管切開術(shù)及麻醉的影響，使實(shí)驗(yàn)過程簡便快捷，并適合長期跟蹤研究。

另外系統(tǒng)可擴(kuò)展連接霧化給藥器，對動物進(jìn)行霧化給藥，建立咳嗽、哮喘等呼吸道疾病模型，系統(tǒng)可檢測和記錄激發(fā)過程中呼吸常規(guī)指標(biāo)和氣道高反應(yīng)的變化，用以評價(jià)支氣管收縮情況。

• 不需要做手術(shù)，操作簡單。

• 動物處于清醒狀態(tài)，結(jié)果不受麻醉和手術(shù)影響。

• 可以實(shí)現(xiàn)在同一只動物上做長期跟蹤實(shí)驗(yàn)。

• 配備氣溶膠霧化模塊 。（可根據(jù)實(shí)驗(yàn)要求選配）

• 可聯(lián)合同步測量其它信號，如體溫、血壓、心電信號等。

小動物頭外置體積描記系統(tǒng)可連接口鼻暴露系統(tǒng)，實(shí)時(shí)在線監(jiān)測動物肺功能指標(biāo)的變化

檢測參數(shù)

小動物頭外置體積描記系統(tǒng)

Ti：吸氣時(shí)間（s）

Te：呼氣時(shí)間（s）

PIF：最大吸氣流速（ml/s）

PEF：最大呼氣流速（ml/s）

Volbal：吸氣時(shí)間/呼氣時(shí)間

F：呼吸頻率（次/min）

Vt：潮氣量（ml）

Mv：分鐘通氣量（ml）

AV：累積體積（ml）

EF50：呼出50%氣量時(shí)對應(yīng)的呼氣流速（ml/s）

EIP：吸氣末暫停時(shí)間

EEP：呼氣末暫停時(shí)間

TR：松弛時(shí)間

PenH：增強(qiáng)呼氣間歇（enhanced pause）

Rpef：相對時(shí)間

小動物頭外置體積描記系統(tǒng)應(yīng)用領(lǐng)域

哮喘Asthma

肺纖維化Lung Fibrosis

慢性阻塞性肺病COPD

急性呼吸系統(tǒng)疾病Acute Respiratory Disorders

模型開發(fā)Model Development

安全評估 Safety Assessment

毒理學(xué)Toxicology

小動物頭外置體積描記系統(tǒng)型號選擇

小動物頭外置體積描記系統(tǒng)用戶名單

小動物頭外置體積描記系統(tǒng)相關(guān)文獻(xiàn)

• [1]Sun Lingna,Fan Mingrui,Huang Dong,Li Bingqin,Xu Ruoting,Gao Feng,Chen Yanzuo. Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis[J]. Biomaterials,2021(prepublish):

• [2]李寧,李紅鵬,張本炎,張柳,沈繼敏,李慶云.高脂膳食對小鼠呼吸功能和膈肌纖維的影響及其線粒體機(jī)制[J].中華醫(yī)學(xué)雜志,2021,101(36):2893-2899.

• [3]Xiong Jiaying,Zhuang Tao,Ma Yurong,Xu Junyi,Ye Jiaqi,Ma Ru,Zhang Shuang,Liu Xin,Liu Bi-Feng,Hao Chao,Zhang Guisen,Chen Yin. Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain[J]. European Journal of Medicinal Chemistry,2021,226:

• [4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang，Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance. Frontiers, 2022.819728:

• [5]Yumei Zhou,  Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang，Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma. Frontiers, 2022. 819747:

• [6]Rui Zheng, Wenhao Yang, Yuting Wen, Liang Xie, Fang Shi, Danli Lu, Jiaxin Luo, Yan Li, Ting Chen, Lina Chen, Wenming Xu and Hanmin Liu.Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening.CDDpress.2022(13:559)：

• [7]Wenyang Wang, Min Mu, Yuanjie Zou, Bing Li,Hangbing Cao, Dong Hu and Xinrong Tao.Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy.PeerJ,DOl 10.7717/2022：

  [8]Dongyi Zhu,Qian Zhang,Qinchuan Li,Guangxue Wang,Zhongliang Guo.Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway.The Journal Gene Medicine.First published: 26 July 2022:

• [9]Jiawen Zhou,Haiyun Chen,Qiuyi Wang,Sihan Chen,Rong Wang,Ziyang Wang,Cuicui Yang,Ao Chen,Jingyu Zhao,Zihao Zhou,Zhiyuan Mao,Guoping Zuo,Dengshun Miao,Jianliang Jin.Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription.Aging Cell WILEY.First published: 30 July 2022：

• [10]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu.Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells.Institute of Special Environmental Medicine, Nantong University, Nantong, 226019, China.Received 7 March 2022, Revised 27 June 2022, Accepted 30 June 2022, Available online 3 July 2022, Version of Record 12 July 2022.

• [11]Mengjun Zhanga,Huiyang Jiang,Lan Wu,Haoyu Lu,Hriday Bera,Xing Zhao,Xiong Guo,Xulu Liu,Dongmei Cun,Mingshi Yang.Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment.Journal of Controlled Release Volume 352, December 2022.

• [12]Xue Lu,Zhu-Xia Tan,Wen-Jing Wang,Ping Zhan,Yan Wang,Lin Fu,Lan Gao,Hui. Zhao,Hua Wang,De-Xiang Xu.Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice.Environmental Pollution Volume 315, 15 December 2022, 120462

• [13]Gu, W., Lei, J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma. Mol Biol Rep 49, 9283–9296 (2022).

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